Drug Interaction Checker
Check for dangerous interactions between your prescription medications, OTC drugs, and supplements. Verify safety before combining medications.
Check Your Medications
Select two medications to check for potential interactions
This tool checks for known interactions between medications. Always consult your pharmacist or physician for personalized advice.
Dangerous Drug Combinations to Avoid
These medication combinations can cause serious harm or death. Never combine these drugs without medical supervision.
Warfarin (Coumadin) + Aspirin (Bayer, Ecotrin)
Increased risk of bleeding when warfarin is combined with aspirin.
Warfarin (Coumadin) + Ibuprofen (Advil, Motrin)
NSAIDs like ibuprofen increase bleeding risk and can cause stomach ulcers in patients on warfarin.
Metformin + contrast-dye
Increased risk of lactic acidosis when metformin is used with iodinated contrast dye.
Sertraline (Zoloft) + Tramadol (Ultram)
Risk of serotonin syndrome when SSRIs are combined with tramadol.
Fluoxetine (Prozac, Sarafem) + Tramadol (Ultram)
High risk of serotonin syndrome. Fluoxetine has a long half-life increasing risk duration.
Oxycodone (OxyContin / Roxicodone) + Alprazolam (Xanax)
Dangerous combination causing severe respiratory depression, coma, and death.
Morphine (MS Contin / Kadian) + Lorazepam (Ativan)
High risk of fatal respiratory depression when opioids are combined with benzodiazepines.
Hydrocodone (Norco / Vicodin) + alcohol
Alcohol increases opioid sedation and respiratory depression. Risk of fatal overdose.
Lisinopril + potassium-supplements
ACE inhibitors + potassium can cause dangerous high potassium levels (hyperkalemia).
Atorvastatin (Lipitor) + Clarithromycin (Biaxin)
Macrolide antibiotics significantly increase statin levels, causing muscle breakdown (rhabdomyolysis).
How to Use the Interaction Checker
1. Select Medications
Choose two medications from our database of 200+ prescription and OTC drugs.
2. Check for Interactions
Our system checks for known drug interactions including severity levels.
3. Review Results
Get detailed information about risks, symptoms to watch for, and management strategies.
Important Medical Disclaimer
This interaction checker is for educational purposes only and does not replace professional medical advice. Always consult your pharmacist or physician before starting, stopping, or combining medications. Our database may not include all possible interactions. If you experience unexpected symptoms, contact your healthcare provider immediately or call emergency services.